natTable.addConfiguration(new DefaultEditBindings() {
     @Override
     public void configureUiBindings(UiBindingRegistry pUiBindingRegistry) {

         pUiBindingRegistry.unregisterSingleClickBinding(new CellEditorMouseEventMatcher(GridRegion.BODY, MouseEventMatcher.LEFT_BUTTON));
		
         CellEditorMouseEventMatcher mouseEventMatcher = new CellEditorMouseEventMatcher(GridRegion.BODY, MouseEventMatcher.LEFT_BUTTON) {
             @Override
             public boolean matches(NatTable pNatTable, MouseEvent pEvent, LabelStack pRegionLabels) 
             {
                 return false;       
             };
         pUiBindingRegistry.registerSingleClickBinding(mouseEventMatcher, new MySelectCellAction());
     }
});

        natTable.addConfiguration(new AbstractUiBindingConfiguration() {
            @Override
            public void configureUiBindings(UiBindingRegistry uiBindingRegistry) {
                uiBindingRegistry.unregisterMouseDownBinding(MouseEventMatcher.bodyLeftClick(SWT.NONE));
                uiBindingRegistry.registerFirstSingleClickBinding(new CellEditorMouseEventMatcher(GridRegion.BODY), new MyAction());
            }
        });

    private class MyAction implements IMouseAction {
        @Override
        public void run(NatTable natTable, MouseEvent event) {
            int cursorCol = natTable.getColumnPositionByX(event.x);
            int cursorRow = natTable.getRowPositionByY(event.y);

            int indexCol = natTable.getColumnIndexByPosition(cursorCol);
            int indexRow = natTable.getRowIndexByPosition(cursorRow);

            boolean isCellSelected = selectionLayer.isCellPositionSelected(indexCol, indexRow);

            if (selectedPreviously) {
                natTable.doCommand(new EditCellCommand(natTable, natTable.getConfigRegistry(), natTable.getCellByPosition(cursorCol, cursorRow)));
            } else {
                natTable.doCommand(new SelectCellCommand(natTable, cursorCol, cursorRow, false, false));
            }
            natTable.redraw();
        }
    }